Combining functional neuroimaging with off-line brain stimulation: modulation of task-related activity in language areas.
Identifieur interne : 000B29 ( Main/Exploration ); précédent : 000B28; suivant : 000B30Combining functional neuroimaging with off-line brain stimulation: modulation of task-related activity in language areas.
Auteurs : Jamila Andoh [Royaume-Uni] ; Tomás PausSource :
- Journal of cognitive neuroscience [ 1530-8898 ] ; 2011.
Descripteurs français
- KwdFr :
- Adulte, Analyse de régression, Analyse de variance, Apprentissage, Cartographie cérébrale, Cortex cérébral (), Cortex cérébral (physiologie), Facteurs temps, Humains, Imagerie par résonance magnétique (), Jeune adulte, Latéralité fonctionnelle, Mâle, Oxygène (sang), Potentiels évoqués auditifs (physiologie), Stimulation acoustique (), Stimulation magnétique transcrânienne (), Temps de réaction (physiologie), Tests neuropsychologiques, Traitement d'image par ordinateur (), Variation contingente négative (physiologie), Vocabulaire.
- MESH :
- physiologie : Cortex cérébral, Potentiels évoqués auditifs, Temps de réaction, Variation contingente négative.
- sang : Oxygène.
- Adulte, Analyse de régression, Analyse de variance, Apprentissage, Cartographie cérébrale, Cortex cérébral, Facteurs temps, Humains, Imagerie par résonance magnétique, Jeune adulte, Latéralité fonctionnelle, Mâle, Stimulation acoustique, Stimulation magnétique transcrânienne, Tests neuropsychologiques, Traitement d'image par ordinateur, Vocabulaire.
English descriptors
- KwdEn :
- Acoustic Stimulation (methods), Adult, Analysis of Variance, Brain Mapping, Cerebral Cortex (blood supply), Cerebral Cortex (physiology), Contingent Negative Variation (physiology), Evoked Potentials, Auditory (physiology), Functional Laterality, Humans, Image Processing, Computer-Assisted (methods), Learning, Magnetic Resonance Imaging (methods), Male, Neuropsychological Tests, Oxygen (blood), Reaction Time (physiology), Regression Analysis, Time Factors, Transcranial Magnetic Stimulation (methods), Vocabulary, Young Adult.
- MESH :
- chemical , blood : Oxygen.
- blood supply : Cerebral Cortex.
- methods : Acoustic Stimulation, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Transcranial Magnetic Stimulation.
- physiology : Cerebral Cortex, Contingent Negative Variation, Evoked Potentials, Auditory, Reaction Time.
- Adult, Analysis of Variance, Brain Mapping, Functional Laterality, Humans, Learning, Male, Neuropsychological Tests, Regression Analysis, Time Factors, Vocabulary, Young Adult.
Abstract
Repetitive TMS (rTMS) provides a noninvasive tool for modulating neural activity in the human brain. In healthy participants, rTMS applied over the language-related areas in the left hemisphere, including the left posterior temporal area of Wernicke (LTMP) and inferior frontal area of Broca, have been shown to affect performance on word recognition tasks. To investigate the neural substrate of these behavioral effects, off-line rTMS was combined with fMRI acquired during the performance of a word recognition task. Twenty right-handed healthy men underwent fMRI scans before and after a session of 10-Hz rTMS applied outside the magnetic resonance scanner. Functional magnetic resonance images were acquired during the performance of a word recognition task that used English or foreign-language words. rTMS was applied over the LTMP in one group of 10 participants (LTMP group), whereas the homologue region in the right hemisphere was stimulated in another group of 10 participants (RTMP group). Changes in task-related fMRI response (English minus foreign languages) and task performances (response time and accuracy) were measured in both groups and compared between pre-rTMS and post-rTMS. Our results showed that rTMS increased task-related fMRI response in the homologue areas contralateral to the stimulated sites. We also found an effect of rTMS on response time for the LTMP group only. These findings provide insights into changes in neural activity in cortical regions connected to the stimulated site and are consistent with a hypothesis raised in a previous review about the role of the homologue areas in the contralateral hemisphere for preserving behavior after neural interference.
DOI: 10.1162/jocn.2010.21449
PubMed: 20146606
Affiliations:
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Le document en format XML
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off-line brain stimulation: modulation of task-related activity in language areas.</title><author><name sortKey="Andoh, Jamila" sort="Andoh, Jamila" uniqKey="Andoh J" first="Jamila" last="Andoh">Jamila Andoh</name><affiliation wicri:level="4"><nlm:affiliation>University of Nottingham, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Nottingham, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Paus, Tomas" sort="Paus, Tomas" uniqKey="Paus T" first="Tomás" last="Paus">Tomás Paus</name></author></analytic><series><title level="j">Journal of cognitive neuroscience</title><idno type="eISSN">1530-8898</idno><imprint><date when="2011" 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Tests</term><term>Regression Analysis</term><term>Time Factors</term><term>Vocabulary</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Analyse de régression</term><term>Analyse de variance</term><term>Apprentissage</term><term>Cartographie cérébrale</term><term>Cortex cérébral</term><term>Facteurs temps</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Jeune adulte</term><term>Latéralité fonctionnelle</term><term>Mâle</term><term>Stimulation acoustique</term><term>Stimulation magnétique transcrânienne</term><term>Tests neuropsychologiques</term><term>Traitement d'image par ordinateur</term><term>Vocabulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Repetitive TMS (rTMS) provides a noninvasive tool for modulating neural activity in the human brain. In healthy participants, rTMS applied over the language-related areas in the left hemisphere, including the left posterior temporal area of Wernicke (LTMP) and inferior frontal area of Broca, have been shown to affect performance on word recognition tasks. To investigate the neural substrate of these behavioral effects, off-line rTMS was combined with fMRI acquired during the performance of a word recognition task. Twenty right-handed healthy men underwent fMRI scans before and after a session of 10-Hz rTMS applied outside the magnetic resonance scanner. Functional magnetic resonance images were acquired during the performance of a word recognition task that used English or foreign-language words. rTMS was applied over the LTMP in one group of 10 participants (LTMP group), whereas the homologue region in the right hemisphere was stimulated in another group of 10 participants (RTMP group). Changes in task-related fMRI response (English minus foreign languages) and task performances (response time and accuracy) were measured in both groups and compared between pre-rTMS and post-rTMS. Our results showed that rTMS increased task-related fMRI response in the homologue areas contralateral to the stimulated sites. We also found an effect of rTMS on response time for the LTMP group only. These findings provide insights into changes in neural activity in cortical regions connected to the stimulated site and are consistent with a hypothesis raised in a previous review about the role of the homologue areas in the contralateral hemisphere for preserving behavior after neural interference.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Nottinghamshire</li></region><settlement><li>Nottingham</li></settlement><orgName><li>Université de Nottingham</li></orgName></list><tree><noCountry><name sortKey="Paus, Tomas" sort="Paus, Tomas" uniqKey="Paus T" first="Tomás" last="Paus">Tomás Paus</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Andoh, Jamila" sort="Andoh, Jamila" uniqKey="Andoh J" first="Jamila" last="Andoh">Jamila Andoh</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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